Meryem Uzerli was born on 12 August 1983 in Kassel, West Germany. Her father, Hüseyin, is Turkish and her mother Ursula, who is also an actress, is German, so she has joint Turkish-German nationality. Her great-grandmother is from Croatia. She embraces and unites both diverse cultures, demonstrated by her two residences in Istanbul and Berlin. Her native language is German, but she is also fluent in Turkish and English. She has two elder brothers and an elder sister, Canan, who is a jazz musician. At the Freie Waldorf School in Kassel, her artistic potential was supported by numerous theater projects. From 2000 until 2003, she studied acting at the Schauspiel Studio Frese in Hamburg. After graduating, she took minor parts in several German productions.